Carpiniello B, Corda E, Maccioni R, Pinna F
Clinica Psichiatrica, Azienda Ospedaliero-Universitaria e Dipartimento di Sanità Pubblica-Sezione di Psichiatria, Università di Cagliari, Cagliari, Italia.
Clin Ter. 2008 Sep-Oct;159(5):299-306.
Obesity seems to be very frequent among schizophrenics, partly due to psychotropic medications. To examine this possibility the authors compared the distribution of Body Mass Index and of Abdominal Obesity among an outpatient sample of schizophrenics, comparing their data with those of the Italian population as a whole.
Weight, height, BMI and waist circumference were evaluated in 126 schizophrenic spectrum outpatients (51 F; 75 M, mean age 43.7 +/- 13.3 yrs) receiving treatment in a university community mental health centre.
Mean BMI of the sample was 26.8 +/- 4.9,without any significant difference between genders (females = 25.9 +/- 4.9; males = 27.4 +/- 4.9). The prevalence of obesity (BMI>or=30) in the sample was 26.2%, 2.8 times higher that of Italian average (9.8%). 46.8% out of the patients was affected by abdominal obesity measuring waist circumference, a prevalence 1.7 times higher that of the Italian average (31%). Abdominal obesity was significantly more frequent among females (F = 60.5%; M= 37.3%, p 0.05). 53% out of those patients who were under treatment with atypical antipsychotics respect to 25% of those who were not under treatment (p>0.05) and 71% of those who were submitted to an association of typical and atypical antipsychotics respect to those patients who were not treated with this association (p 0.05) were affected by abdominal obesity.
Also in Italy schizophrenic were found more frequently obese than the corresponding general population. Female schizophrenics and patients who undergone treatment with atypical antipsychotics or with the combination of typical and atypical antipsychotics were significantly more at risk for abdominal obesity.
肥胖在精神分裂症患者中似乎非常常见，部分原因是精神药物的使用。为了检验这种可能性，作者比较了精神分裂症门诊患者样本中的体重指数和腹部肥胖分布情况，并将他们的数据与意大利全体人群的数据进行了比较。
在一所大学社区心理健康中心接受治疗的126名精神分裂症谱系门诊患者（51名女性；75名男性，平均年龄43.7±13.3岁）中评估了体重、身高、体重指数和腰围。
样本的平均体重指数为26.8±4.9，男女之间无显著差异（女性=25.9±4.9；男性=27.4±4.9）。样本中肥胖（体重指数≥30）的患病率为26.2%，是意大利平均水平（9.8%）的2.8倍。46.8%的患者存在腹部肥胖（通过测量腰围），患病率是意大利平均水平（31%）的1.7倍。腹部肥胖在女性中更为常见（女性=60.5%；男性=37.3%，p<0.05）。接受非典型抗精神病药物治疗的患者中有53%存在腹部肥胖，而未接受治疗的患者中这一比例为25%（p>0.05）；接受典型和非典型抗精神病药物联合治疗的患者中有71%存在腹部肥胖，而未接受这种联合治疗的患者中这一比例为（p<0.05）。
在意大利，精神分裂症患者的肥胖发生率也高于相应的普通人群。女性精神分裂症患者以及接受非典型抗精神病药物治疗或接受典型和非典型抗精神病药物联合治疗的患者腹部肥胖风险显著更高。
