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来自干巴菌(Thelephora ganbajun)的天然对三联苯衍生物的抗氧化特性。

Antioxidant properties of natural p-terphenyl derivatives from the mushroom Thelephora ganbajun.

作者信息

Yang Wei-Min, Liu Ji-Kai, Hu Lin, Dong Ze-Jun, Wu Wan-Lin, Chen Zhi-He

机构信息

Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, P.R. China.

出版信息

Z Naturforsch C J Biosci. 2004 May-Jun;59(5-6):359-62. doi: 10.1515/znc-2004-5-612.

DOI:10.1515/znc-2004-5-612
PMID:18998401
Abstract

The antioxidant activity in vitro of three poly(phenylacetyloxy)-substituted 1,1':4',1"-terphenyl compounds from the edible mushroom Thelephora ganbajun were investigated. The IC50 values of compounds 1-3 for lipid peroxidation in rat liver homogenate were 400, 48, 54 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 values of 182, 74, 204 microM. They were also assessed on the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity with EC50 values of 49, 1233, 55 microM.

摘要

对采自食用菌干巴菌的三种聚(苯乙酰氧基)取代的1,1':4',1''-三联苯化合物的体外抗氧化活性进行了研究。化合物1-3对大鼠肝匀浆脂质过氧化的IC50值分别为400、48、54微摩尔。化合物1-3使超氧化物歧化酶(SOD)活性增加,其EC50值为182、74、204微摩尔。还对它们的1,1-二苯基-2-苦基肼(DPPH)自由基清除活性进行了评估,其EC50值为49、1233、55微摩尔。

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