Sun Jie, Shi Cheng-Ren, Xi Ye-Bin, Li Wei-Yi, Li Huai-Yuan
Department of Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Zhonghua Nan Ke Xue. 2008 Sep;14(9):823-5.
To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.
Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.
After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.
Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
观察大鼠睾丸间质细胞同种异体移植后血清睾酮的变化。
采用Percoll技术从SD大鼠睾丸中分离间质细胞，连续3个月每月测定1次受体血清睾酮水平。
睾丸间质细胞同种异体移植后，受体血清睾酮水平逐渐升高，3个月时显著高于2月龄正常大鼠。
睾丸间质细胞同种异体移植在男性原发性性腺功能减退症治疗中具有良好的应用价值。
