超氧自由基对牛红细胞膜的影响。
Effect of hyperoxide radicals on bovine-erythrocyte membrane.
作者信息
Bartosz G, Fried R, Grzelińska E, Leyko W
出版信息
Eur J Biochem. 1977 Feb 15;73(1):261-4. doi: 10.1111/j.1432-1033.1977.tb11315.x.
Abstract
- Bovine erythrocytes exposed to the action of an enzymic source of hyperoxide radicals (hypoxanthine + xanthine oxidase) exhibited hemolysis, which was prevented by the presence of hyperoxide dismutase. 2. Exposing bovine erythrocyte membranes to the source of hyperoxide radicals resulted in a decrease of (Mg2+ + Na+ + K+)ATPase activity which could be partially prevented by addition of hyperoxide dismutase. 3. The damage observed to erythrocyte membranes under the conditions applied is ascribed to toh formed in the Haber and Weiss reaction since a protection by OH scavengers was also observed.
摘要
- 暴露于超氧自由基酶源（次黄嘌呤+黄嘌呤氧化酶）作用下的牛红细胞出现溶血现象，而超氧化物歧化酶的存在可防止这种溶血。2. 将牛红细胞膜暴露于超氧自由基源会导致（Mg2++Na++K+）ATP酶活性降低，添加超氧化物歧化酶可部分防止这种降低。3. 在所用条件下观察到的红细胞膜损伤归因于哈伯-韦斯反应中形成的羟自由基，因为也观察到了羟自由基清除剂的保护作用。
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