伏立康唑滴眼液溶液的制备与稳定性
Preparation and stability of voriconazole eye drop solution.
作者信息
Dupuis Antoine, Tournier Nicolas, Le Moal Gwenaël, Venisse Nicolas
机构信息
Centre Hospitalier Universitaire de Poitiers, France.
出版信息
Antimicrob Agents Chemother. 2009 Feb;53(2):798-9. doi: 10.1128/AAC.01126-08. Epub 2008 Nov 10.
Abstract
The combined systemic and topical administration of voriconazole has successfully been used to treat keratomycosis. Because no voriconazole eye drop product is commercially available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable over 30 days, providing an eye drop solution suitable for use for the topical treatment of fungal keratitis.
摘要
伏立康唑的全身及局部联合给药已成功用于治疗角膜真菌病。由于尚无市售的伏立康唑滴眼液产品，我们制备了一种无菌滴眼液溶液（10毫克/毫升）。伏立康唑在30天内保持稳定，提供了一种适用于真菌性角膜炎局部治疗的滴眼液溶液。
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