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本文引用的文献

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Voriconazole for the treatment of refractory Aspergillus fumigatus keratitis.伏立康唑用于治疗难治性烟曲霉角膜炎。
Indian J Ophthalmol. 2008 May-Jun;56(3):243-5. doi: 10.4103/0301-4738.40369.
2
Penetration of voriconazole, 1%, eyedrops into human aqueous humor: a prospective open-label study.1%伏立康唑滴眼液在人房水中的渗透：一项前瞻性开放标签研究。
Arch Ophthalmol. 2008 Mar;126(3):343-6. doi: 10.1001/archophthalmol.2007.71.
3
[Fortified antibiotic (vancomycin, amikacin and ceftazidime) eye drop stability assessment at -20 degrees C].[强化抗生素（万古霉素、阿米卡星和头孢他啶）滴眼液在-20℃下的稳定性评估]
J Fr Ophtalmol. 2007 Oct;30(8):807-13. doi: 10.1016/s0181-5512(07)92614-5.
4
Voriconazole : a review of its use in the management of invasive fungal infections.伏立康唑：关于其在侵袭性真菌感染治疗中应用的综述
Drugs. 2007;67(2):269-98. doi: 10.2165/00003495-200767020-00009.
5
Topical and oral voriconazole in the treatment of fungal keratitis.局部及口服伏立康唑治疗真菌性角膜炎
Am J Ophthalmol. 2007 Jan;143(1):151-3. doi: 10.1016/j.ajo.2006.07.033. Epub 2006 Aug 31.
6
Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.局部或局部与全身联合给药治疗真菌性角膜炎时人房水和血浆中的伏立康唑浓度。
Antimicrob Agents Chemother. 2007 Jan;51(1):239-44. doi: 10.1128/AAC.00762-06. Epub 2006 Oct 23.
7
Voriconazole in fungal keratitis caused by Scedosporium apiospermum.伏立康唑治疗由尖端赛多孢子菌引起的真菌性角膜炎。
Ann Pharmacother. 2004 Mar;38(3):414-7. doi: 10.1345/aph.1D128. Epub 2004 Jan 30.
8
Use of voriconazole in Scedosporium apiospermum keratitis.伏立康唑在尖端赛多孢菌角膜炎中的应用。
Cornea. 2003 May;22(4):391; discussion 391-2. doi: 10.1097/00003226-200305000-00024.
9
Fungal keratitis caused by Scedosporium apiospermum: report of two cases and review of treatment.由尖端赛多孢菌引起的真菌性角膜炎：两例报告及治疗综述
Cornea. 2002 Jul;21(5):519-23. doi: 10.1097/00003226-200207000-00016.
10
Severe keratomycosis secondary to Scedosporium apiospermum.由尖端赛多孢菌引起的严重角膜真菌病。
Cornea. 2002 Jul;21(5):516-8. doi: 10.1097/00003226-200207000-00015.

伏立康唑滴眼液溶液的制备与稳定性

Preparation and stability of voriconazole eye drop solution.

作者信息

Dupuis Antoine, Tournier Nicolas, Le Moal Gwenaël, Venisse Nicolas

机构信息

Centre Hospitalier Universitaire de Poitiers, France.

出版信息

Antimicrob Agents Chemother. 2009 Feb;53(2):798-9. doi: 10.1128/AAC.01126-08. Epub 2008 Nov 10.

DOI:10.1128/AAC.01126-08
PMID:19001119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2630666/
Abstract

The combined systemic and topical administration of voriconazole has successfully been used to treat keratomycosis. Because no voriconazole eye drop product is commercially available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable over 30 days, providing an eye drop solution suitable for use for the topical treatment of fungal keratitis.

摘要

伏立康唑的全身及局部联合给药已成功用于治疗角膜真菌病。由于尚无市售的伏立康唑滴眼液产品，我们制备了一种无菌滴眼液溶液（10毫克/毫升）。伏立康唑在30天内保持稳定，提供了一种适用于真菌性角膜炎局部治疗的滴眼液溶液。