Rogers Peter A W, Donoghue Jacqueline F, Walter Lisa M, Girling Jane E
Centre for Women's Health Research, Monash University, Department of Obstetrics and Gynaecology and Monash Institute for Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Reprod Sci. 2009 Feb;16(2):147-51. doi: 10.1177/1933719108325509. Epub 2008 Nov 11.
Angiogenesis, arteriogenesis or vessel maturation, and lymphangiogenesis comprise a continuum of vascular development, with overlap and interaction between the mechanisms by which they are controlled. These processes are of clinical interest because they play roles in endometrial repair, placental development, and in gynecological disorders including endometrial cancer, endometriosis and abnormal uterine bleeding. Using mouse models we have shown that estrogen can be either proangiogenic or antiangiogenic in endometrium. Progesterone alone is proangiogenic, although this can be moderated by pretreatment with estrogen. Arteriogenesis also increases in response to progesterone, and this effect is not inhibited by estrogen. Lymphatics account for 13% of all vessels in the human functionalis compared to 57% in the basalis. Many of the basalis lymphatic vessels are closely associated with spiral arterioles and this intimate connection may provide a mechanism for paracrine communication between the functionalis and the arteries supplying the endometrium.
血管生成、动脉生成或血管成熟以及淋巴管生成构成了血管发育的连续过程，它们的调控机制之间存在重叠和相互作用。这些过程具有临床意义，因为它们在子宫内膜修复、胎盘发育以及包括子宫内膜癌、子宫内膜异位症和异常子宫出血在内的妇科疾病中发挥作用。我们利用小鼠模型表明，雌激素在子宫内膜中既可以是促血管生成的，也可以是抗血管生成的。单独使用孕激素具有促血管生成作用，尽管这可以通过雌激素预处理来调节。动脉生成也会因孕激素而增加，且这种作用不受雌激素抑制。在人类功能层中，淋巴管占所有血管的13%，而在基底层中占57%。许多基底层淋巴管与螺旋小动脉密切相关，这种紧密联系可能为功能层与供应子宫内膜的动脉之间的旁分泌通讯提供一种机制。
