Rose Shelonitda S, Ali Yaqoob, Kumar Amit, Bekos Teri Jo, Saidi Parvin
Division of Hematology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.
Am J Med Sci. 2009 Jan;337(1):67-70. doi: 10.1097/MAJ.0b013e31816a8d0d.
Inferior vena cava (IVC) atresia is a risk factor for deep vein thrombosis (DVT) in young patients. Although Doppler ultrasound diagnoses DVT, a contrast-enhanced computerized tomography (CT) or magnetic resonance angiography (MRA) diagnoses IVC atresia, other congenital IVC anomalies and must be considered in young patients presenting with idiopathic DVT. Patients with IVC atresia associated with hereditary thrombophilia are at increased risk for recurrent DVT and may require long-term anticoagulation. We report 2 cases: the first one, a 33-year-old man with lower extremity DVT caused by IVC atresia in association with multiple thrombophilic risk factors; the second one, a 34-year-old woman with lower extremity DVT caused by IVC atresia in association with prothrombin gene mutation. To our knowledge, this association has not been reported. The clinical presentation, tools for diagnosis, and the need for long-term anticoagulation are discussed.
下腔静脉（IVC）闭锁是年轻患者发生深静脉血栓形成（DVT）的一个危险因素。尽管多普勒超声可诊断DVT，但对比增强计算机断层扫描（CT）或磁共振血管造影（MRA）可诊断IVC闭锁、其他先天性IVC异常，对于出现特发性DVT的年轻患者必须考虑这些情况。伴有遗传性易栓症的IVC闭锁患者复发性DVT风险增加，可能需要长期抗凝治疗。我们报告2例病例：第一例是一名33岁男性，因IVC闭锁合并多种易栓危险因素导致下肢DVT；第二例是一名34岁女性，因IVC闭锁合并凝血酶原基因突变导致下肢DVT。据我们所知，这种关联尚未见报道。本文讨论了其临床表现、诊断方法以及长期抗凝治疗的必要性。
