Dreiher Jacob, Weitzman Dahlia, Davidovici Batya, Shapiro Jonathan, Cohen Arnon D
Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva, Israel.
Acta Derm Venereol. 2008;88(6):561-5. doi: 10.2340/00015555-0510.
Previous reports demonstrated an association between psoriasis and the metabolic syndrome. The aim of this study was to elucidate the association between psoriasis and dyslipidaemia. A cross-sectional study was performed utilizing a population-based database. Psoriasis patients were compared with enrollees without psoriasis regarding the prevalence of dyslipidaemia and lipid levels. Comparison of lipid levels was performed on a "low-risk" subset of subjects without diabetes, hypertension and cardiovascular disease. The study included 10,669 psoriasis patients and 22,996 subjects without psoriasis. The prevalence of dyslipidaemia was significantly higher in psoriasis patients (odds ratio (OR) = 1.48, 95% confidence interval (CI) 1.40-1.55). The association remained significant after controlling for confounders (OR = 1.19, 95% CI 1.12-1.26, p < 0.001). In multivariate analysis of the "low-risk" subset, triglyceride levels were higher in psoriasis patients and high-density lipoprotein cholesterol levels were lower. This study supports previous reports of an association between psoriasis and lipid abnormalities.
既往报告显示银屑病与代谢综合征之间存在关联。本研究的目的是阐明银屑病与血脂异常之间的关联。利用一个基于人群的数据库进行了一项横断面研究。将银屑病患者与无银屑病的入组者在血脂异常患病率和血脂水平方面进行比较。在无糖尿病、高血压和心血管疾病的“低风险”受试者亚组中进行血脂水平比较。该研究纳入了10669例银屑病患者和22996例无银屑病的受试者。银屑病患者血脂异常的患病率显著更高（优势比（OR）=1.48，95%置信区间（CI）1.40 - 1.55）。在控制混杂因素后，该关联仍然显著（OR = 1.19，95% CI 1.12 - 1.26，p < 0.001）。在“低风险”亚组的多变量分析中，银屑病患者的甘油三酯水平较高，高密度脂蛋白胆固醇水平较低。本研究支持既往关于银屑病与脂质异常之间存在关联的报告。
