Ozdemir Mustafa, Engin Burhan, Baysal Ibrahim, Mevlitoğlu Inci
Department of Dermatology, Meram Medical Faculty, Selcuk University, Konya, Turkey.
Acta Derm Venereol. 2008;88(6):589-93. doi: 10.2340/00015555-0529.
The combination of retinoids with phototherapy enhances the efficacy of phototherapy and reduces the cumulative ultraviolet dose and duration of the therapy needed to treat chronic plaque psoriasis. Although TL-01 phototherapy has been used widely, there are few data about the effectiveness of the combination of acitretin with TL-01 in treatment of the disease. The aim of this study was to compare acitretin-narrow-band TL-01 phototherapy with acitretin-psoralen plus ultraviolet A (acitretin-PUVA) in psoriasis. We studied 60 patients with moderate to severe plaque psoriasis who were randomly allocated to three times weekly treatment acitretin-narrow-band TL-01 or acitretin-PUVA. The efficacy of treatments was assessed using the Psoriasis Area and Severity Index by a blinded observer. Clearance of psoriasis was achieved in 56.6% of patients treated with acitretin-narrow-band TL-01 and in 63.3% of those treated with acitretin-PUVA. All of these patients remained clear of psoriasis 3 months after finishing the treatments. Mucocutaneous side-effects, such as dry lips and mouth, were the most common complaints in both groups. In conclusion, acitretin-narrow-band TL-01 is an effective and well-tolerated treatment for moderate to severe plaque psoriasis, with a therapeutic effect equal to that of acitretin-PUVA.
维甲酸与光疗联合使用可提高光疗效果,减少治疗慢性斑块状银屑病所需的紫外线累积剂量和治疗持续时间。尽管TL-01光疗已被广泛应用,但关于阿维A与TL-01联合治疗该病有效性的数据却很少。本研究旨在比较阿维A-窄谱TL-01光疗与阿维A-补骨脂素加紫外线A(阿维A-PUVA)治疗银屑病的效果。我们研究了60例中度至重度斑块状银屑病患者,将其随机分配接受每周3次的阿维A-窄谱TL-01或阿维A-PUVA治疗。由一名盲法观察者使用银屑病面积和严重程度指数评估治疗效果。接受阿维A-窄谱TL-01治疗的患者中有56.6%银屑病清除,接受阿维A-PUVA治疗的患者中有63.3%银屑病清除。所有这些患者在完成治疗3个月后仍无银屑病复发。两组中最常见的不良反应均为黏膜皮肤副作用,如口干唇干。总之,阿维A-窄谱TL-01是治疗中度至重度斑块状银屑病的一种有效且耐受性良好的疗法,其治疗效果与阿维A-PUVA相当。