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阿维A联合窄谱中波紫外线(TL-01)光疗与阿维A联合补骨脂素加紫外线A治疗银屑病的随机对照研究

A randomized comparison of acitretin-narrow-band TL-01 phototherapy and acitretin-psoralen plus ultraviolet A for psoriasis.

作者信息

Ozdemir Mustafa, Engin Burhan, Baysal Ibrahim, Mevlitoğlu Inci

机构信息

Department of Dermatology, Meram Medical Faculty, Selcuk University, Konya, Turkey.

出版信息

Acta Derm Venereol. 2008;88(6):589-93. doi: 10.2340/00015555-0529.

Abstract

The combination of retinoids with phototherapy enhances the efficacy of phototherapy and reduces the cumulative ultraviolet dose and duration of the therapy needed to treat chronic plaque psoriasis. Although TL-01 phototherapy has been used widely, there are few data about the effectiveness of the combination of acitretin with TL-01 in treatment of the disease. The aim of this study was to compare acitretin-narrow-band TL-01 phototherapy with acitretin-psoralen plus ultraviolet A (acitretin-PUVA) in psoriasis. We studied 60 patients with moderate to severe plaque psoriasis who were randomly allocated to three times weekly treatment acitretin-narrow-band TL-01 or acitretin-PUVA. The efficacy of treatments was assessed using the Psoriasis Area and Severity Index by a blinded observer. Clearance of psoriasis was achieved in 56.6% of patients treated with acitretin-narrow-band TL-01 and in 63.3% of those treated with acitretin-PUVA. All of these patients remained clear of psoriasis 3 months after finishing the treatments. Mucocutaneous side-effects, such as dry lips and mouth, were the most common complaints in both groups. In conclusion, acitretin-narrow-band TL-01 is an effective and well-tolerated treatment for moderate to severe plaque psoriasis, with a therapeutic effect equal to that of acitretin-PUVA.

摘要

维甲酸与光疗联合使用可提高光疗效果,减少治疗慢性斑块状银屑病所需的紫外线累积剂量和治疗持续时间。尽管TL-01光疗已被广泛应用,但关于阿维A与TL-01联合治疗该病有效性的数据却很少。本研究旨在比较阿维A-窄谱TL-01光疗与阿维A-补骨脂素加紫外线A(阿维A-PUVA)治疗银屑病的效果。我们研究了60例中度至重度斑块状银屑病患者,将其随机分配接受每周3次的阿维A-窄谱TL-01或阿维A-PUVA治疗。由一名盲法观察者使用银屑病面积和严重程度指数评估治疗效果。接受阿维A-窄谱TL-01治疗的患者中有56.6%银屑病清除,接受阿维A-PUVA治疗的患者中有63.3%银屑病清除。所有这些患者在完成治疗3个月后仍无银屑病复发。两组中最常见的不良反应均为黏膜皮肤副作用,如口干唇干。总之,阿维A-窄谱TL-01是治疗中度至重度斑块状银屑病的一种有效且耐受性良好的疗法,其治疗效果与阿维A-PUVA相当。

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