Nielsen Forrest H
U.S. Department of Agriculture, Grand Forks Human Nutrition Research Center, ND, 58202-9034, USA.
Biol Trace Elem Res. 2009 Jun;128(3):220-31. doi: 10.1007/s12011-008-8268-7. Epub 2008 Nov 11.
An experiment with rats was conducted to determine whether magnesium retention is increased and calcium utilization is altered by a marginal zinc deficiency and whether increased oxidative stress induced by a marginal copper deficiency exacerbated responses to a marginal zinc deficiency. Weanling rats were assigned to six groups of ten with dietary treatment variables of low zinc (5 mg/kg for 2 weeks and 8 mg/kg for 7 weeks), low copper (1.5 mg/kg), adequate zinc (15 mg/kg), and adequate copper (6 mg/kg). Two groups of rats were fed the adequate-zinc diet with low or adequate copper and pair-fed with corresponding rats fed the low-zinc diet. When compared to the pair-fed rats, marginal zinc deficiency significantly decreased the urinary excretion of magnesium and calcium, increased the concentrations of magnesium and calcium in the tibia, increased the concentration of magnesium in the kidney, and increased the urinary excretion of helical peptide (bone breakdown product). Marginal copper deficiency decreased extracellular superoxide dismutase and glutathione, which suggests increased oxidative stress. None of the variables responding to the marginal zinc deficiency were significantly altered by the marginal copper deficiency. The findings in the present experiment suggest that increased magnesium retention and impaired calcium utilization are indicators of marginal zinc deficiency.
进行了一项用大鼠的实验，以确定边缘性锌缺乏是否会增加镁的潴留并改变钙的利用，以及边缘性铜缺乏所诱导的氧化应激增加是否会加剧对边缘性锌缺乏的反应。将断奶大鼠分为六组，每组十只，饮食处理变量包括低锌（2周5毫克/千克，7周8毫克/千克）、低铜（1.5毫克/千克）、充足锌（15毫克/千克）和充足铜（6毫克/千克）。两组大鼠喂食含低铜或充足铜的充足锌饮食，并与喂食低锌饮食的相应大鼠进行配对喂养。与配对喂养的大鼠相比，边缘性锌缺乏显著降低了镁和钙的尿排泄量 , 增加了胫骨中镁和钙的浓度，增加了肾脏中镁的浓度，并增加了螺旋肽（骨分解产物）的尿排泄量。边缘性铜缺乏降低了细胞外超氧化物歧化酶和谷胱甘肽，这表明氧化应激增加。边缘性铜缺乏对任何因边缘性锌缺乏而产生反应的变量均无显著影响。本实验的结果表明，镁潴留增加和钙利用受损是边缘性锌缺乏的指标。
