Derici Ulver, Tuncer Candan, Ebinç Fatma Ayerden, Mutluay Ruya, Yakaryilmaz Fahri, Kulaksizoglu Sevsen, Soylemezoglu Oguz, Sindel Sukru
Nephrology Department, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey.
Adv Ther. 2008 Dec;25(12):1342-52. doi: 10.1007/s12325-008-0109-8.
There remains some difficulty in determining disease activity during the development of inflammatory bowel disease (IBD). The excretion levels of some inflammatory response molecules increase as a result of the onset of this disease. We studied urinary alfa-1-microglobulin (alpha1-MG) and albumin levels in patients with active and inactive ulcerative colitis (UC) and investigated whether we could use these parameters as an activity index.
The study was carried out at Gazi University Faculty of Medicine, Nephrology and Gastroenterology Departments, between December 2003 and March 2006. In total, 35 patients (male/female: 16/19, mean age: 38.3+/-2.4 years) and 13 healthy controls (male/female: 6/7, mean age: 35.8+/-2.8 years) were enrolled in the study. Nineteen patients had symptoms of active disease and the remaining 16 patients had inactive disease.
There was a significant difference in serum C-reactive protein (CRP), urinary albumin excretion, and alpha1-MG excretion levels between patients and controls. Patients with active disease had significantly higher serum CRP and alpha1-MG levels than those with inactive disease and controls. Patients with active disease had higher microalbuminuria levels than inactive patients, but this difference was not statistically significant. Urinary albumin and alpha1-MG excretion did not correlate with serum CRP levels.
The present study suggests that, as with CRP, urinary levels of albumin and alpha1-MG increase during the active period of UC. During the inactive period, concentrations of these parameters are comparable to controls. The measurement of alpha1-MG and/or microalbuminuria could provide information on disease severity and response to treatment.
在炎症性肠病（IBD）的发展过程中，确定疾病活动度仍存在一些困难。由于这种疾病的发作，一些炎症反应分子的排泄水平会升高。我们研究了活动期和非活动期溃疡性结肠炎（UC）患者的尿α1-微球蛋白（α1-MG）和白蛋白水平，并调查了我们是否可以将这些参数用作活动指数。
该研究于2003年12月至2006年3月在加齐大学医学院肾脏病学和胃肠病学系进行。共有35例患者（男/女：16/19，平均年龄：38.3±2.4岁）和13名健康对照者（男/女：6/7，平均年龄：35.8±2.8岁）纳入研究。19例患者有疾病活动症状，其余16例患者疾病处于非活动期。
患者与对照者之间的血清C反应蛋白（CRP）、尿白蛋白排泄和α1-MG排泄水平存在显著差异。活动期疾病患者的血清CRP和α1-MG水平显著高于非活动期疾病患者和对照者。活动期疾病患者的微量白蛋白尿水平高于非活动期患者，但这种差异无统计学意义。尿白蛋白和α1-MG排泄与血清CRP水平无关。
本研究表明，与CRP一样，UC活动期尿白蛋白和α1-MG水平会升高。在非活动期，这些参数的浓度与对照者相当。测量α1-MG和/或微量白蛋白尿可以提供有关疾病严重程度和治疗反应的信息。
