评估临床孤立综合征中的亚临床认知功能障碍及事件相关电位（P300）
Evaluating sub-clinical cognitive dysfunction and event-related potentials (P300) in clinically isolated syndrome.
作者信息
Kocer Belgin, Unal Tugba, Nazliel Bijen, Biyikli Zeynep, Yesilbudak Zulal, Karakas Sirel, Irkec Ceyla
机构信息
Department of Neurology, Gazi University Medical Faculty, Nöroloji Anabilim Dali, Beşevler, Cankaya, Turkey.
出版信息
Neurol Sci. 2008 Dec;29(6):435-44. doi: 10.1007/s10072-008-1020-4. Epub 2008 Nov 11.
OBJECTIVE
This study investigated the presence of sub-clinical cognitive dysfunction in patients with clinically isolated syndrome (CIS) and the abnormalities of cognitive event-related potentials (ERPs).
METHODS
Subclinical cognitive dysfunction was assessed in 20 patients with CIS and in 20 healthy controls.
RESULTS
Patients had impairments in verbal learning and long-term memory, evaluating attention, executive function and visuospatial skills, in decreasing order of frequency. SDLT and SIT were the most, and COWAT and BNT were the least affected tests. The N200 and P200 latencies were prolonged, and N100, N200 and P200 amplitudes were reduced in the patients relative to the controls, from the Fz, Cz and Pz electrode positions (p<0.05).
CONCLUSION
Detailed cognitive testing is valuable in determining subclinical cognitive dysfunction in CIS patients. ERP abnormalities as well as abnormalities in detailed cognitivetesting in patients with CIS are helpful in the diagnosis of sub-clinical cognitive dysfunction.
目的
本研究调查临床孤立综合征（CIS）患者亚临床认知功能障碍的存在情况以及认知事件相关电位（ERP）的异常。
方法
对20例CIS患者和20名健康对照者进行亚临床认知功能障碍评估。
结果
患者在言语学习、长期记忆、注意力评估、执行功能和视觉空间技能方面存在损害，频率依次降低。SDLT和SIT受影响最大，COWAT和BNT受影响最小。与对照组相比，患者从Fz、Cz和Pz电极位置处的N200和P200潜伏期延长，N100、N200和P200波幅降低（p<0.05）。
结论
详细的认知测试对于确定CIS患者的亚临床认知功能障碍具有重要价值。CIS患者的ERP异常以及详细认知测试中的异常有助于亚临床认知功能障碍的诊断。
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