Magnano I, Aiello I, Piras M R
Institute of Clinical Neurology, University of Sassari, Viale S. Pietro 10, 07100 Sassari, Italy.
J Neurol Sci. 2006 Jun 15;245(1-2):117-22. doi: 10.1016/j.jns.2005.08.027. Epub 2006 May 11.
Cognitive impairment in multiple sclerosis (MS) has received considerable interest over the last decades. Heterogeneous patterns of cognitive dysfunction have been reported in literature in relation to the subtype of the disease and the severity of specific cognitive domains affected. Event related potentials (ERPs), especially P300, have been employed to evaluate the cognitive decline in MS and neurophysiological findings agree with data obtained by neuropsychological testing. The objectivity, the reliability and the easy administration are the main features of ERP technique but more specific attention and memory tasks are needed to enhance the clinical value of the methodology. Moreover, ERP recording has the advantage of being feasible even in severe disabled patients. Finally, longitudinal ERP studies are required to investigate the natural course of cognitive dysfunction in MS, to estimate the prognostic value of subclinical defects in different clinical form of the disease and to evaluate clinical benefits of therapeutic and rehabilitative interventions.
在过去几十年中，多发性硬化症（MS）中的认知障碍受到了广泛关注。文献报道了与疾病亚型以及受影响的特定认知领域严重程度相关的认知功能障碍的异质性模式。事件相关电位（ERP），尤其是P300，已被用于评估MS中的认知衰退，并且神经生理学发现与通过神经心理学测试获得的数据一致。ERP技术的主要特点是客观性、可靠性和易于实施，但需要更具体的注意力和记忆任务来提高该方法的临床价值。此外，即使在严重残疾患者中，ERP记录也具有可行性。最后，需要进行纵向ERP研究，以调查MS中认知功能障碍的自然病程，估计疾病不同临床形式中亚临床缺陷的预后价值，并评估治疗和康复干预的临床益处。
