由主要穹窿蛋白 LRP 表达决定的与穹窿相关的抗癌药物耐药性。
Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.
机构信息
Department of Medical Oncology, Catalan Institute of Oncology, Av. Casteldefels Km 2.7, 08907 Hospitalet de LI., Barcelona, Spain.
出版信息
Cytotechnology. 1998 Sep;27(1-3):137-48. doi: 10.1023/A:1008004502861.
Abstract
In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.
摘要
在这篇综述中，我们分析了支持 vault 相关多药耐药性（LRP/MVP 过表达）作为体外和临床耐药标志物的观点的数据。Vaults 除了发挥基本的生物学作用外，还可能参与一种新的多药耐药机制。
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