癌基因在耐药性中的作用。
The role of oncogenes in drug resistance.
机构信息
Departments of Surgical Oncology and Tumor Biology, The University of Texas, M.D. Anderson Cancer Center, Box 107, Houston, TX, 77030, U.S.A.,
出版信息
Cytotechnology. 1998 Sep;27(1-3):283-92. doi: 10.1023/A:1008053913764.
Increasing evidences indicate that oncogenes can directly or indirectly impact on cancer-cell drug resistance. This chapter provides a conceptual review regarding the role of oncogenes in drug resistance. The review is focused on drug resistance mediated by oncogenes encoding growth factor receptors, signaling molecules, transcription factors, cell-cycle regulators, and apoptosis regulators. It is my hope that better undertsnading on the role of oncogenes in drug resistance will invoke ideas on new approaches to enhance the cytotoxicity of the standard chemotherapeutic agents by functional perturbation of resistance-inducing oncogenes.
越来越多的证据表明，癌基因可以直接或间接地影响癌细胞的耐药性。本章就癌基因在耐药性中的作用进行了概念性的综述。综述主要集中于生长因子受体、信号分子、转录因子、细胞周期调节因子和凋亡调节因子编码的癌基因介导的耐药性。希望更好地理解癌基因在耐药性中的作用，能够激发人们的想法，通过功能干扰诱导耐药性的癌基因，来提高标准化疗药物的细胞毒性。
Zotero 插件