人类造血干细胞移植的扩增：趋势与展望。
Expansion of human hematopoietic stem cells for transplantation: trends and perspectives.
机构信息
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José 2055 Col. Lomas 4 Sección, CP 78216, San Luis Potosi, S.L.P., Mexico.
出版信息
Cytotechnology. 2008 Mar;56(3):151-60. doi: 10.1007/s10616-008-9144-1. Epub 2008 Mar 29.
Abstract
Umbilical cord blood transplantation is clinically limited by its low progenitor cell content. Ex vivo expansion has become an alternative to increase the cell dose available for transplants. Expansion has been evaluated in several ways such as static cultures combining growth factors or mimicking the natural microenvironment using co-culture systems. However, static cultures have a small volume capacity and therefore large-scale expansion has been addressed using bioreactors. These and other biotechnological approaches for the expansion of hematopoietic progenitors and their utility to study several aspects of hematopoietic stem cell biology are discussed here.
摘要
脐带血移植在临床上受到其祖细胞含量低的限制。体外扩增已成为增加可用于移植的细胞剂量的一种替代方法。已经以几种方式评估了扩增，例如结合生长因子的静态培养或使用共培养系统模拟自然微环境。然而，静态培养的容量较小，因此使用生物反应器来解决大规模扩增的问题。本文讨论了用于扩增造血祖细胞的这些和其他生物技术方法及其在研究造血干细胞生物学几个方面的应用。
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