Department of Pathology, New York University School of Medicine, New York, NY, U.S.A. (E-mail,
Cytotechnology. 2003 Mar;41(2-3):139-44. doi: 10.1023/A:1024826823194.
The capacity of hepatocytes and cholangiocytes to contribute to their own maintenance has long been recognized. More recently, studies have indicated the presence of both intra-hepatic and extra-hepatic stem/progenitor cell populations. The intraorgan compartment probably derives primarily from the biliary tree, most particularly the most proximal branches, i.e. the canals of Hering and smallest ductules. The extra-organ compartment is at least in part derived from diverse populations of cells from the bone marrow. These three tiers of liver cell regeneration serve to maintain the normal organ and to regenerate damaged parenchyma in response to a variety of insults. The nature and extent of the insult determines the balance between these stem/progenitor compartments.
长期以来，人们一直认为肝细胞和胆管细胞有能力自我维持。最近的研究表明，存在肝内和肝外干细胞/祖细胞群体。器官内隔室可能主要来源于胆管系统，特别是最近端的分支，即 Hering 管和最小的细胆管。器官外隔室至少部分来源于骨髓中的各种细胞群体。这三个层次的肝细胞再生有助于维持正常器官，并在受到各种损伤时再生受损的实质。损伤的性质和程度决定了这些干细胞/祖细胞隔室之间的平衡。
