Theise Neil D
Department of Pathology, New York University School of Medicine, Room 461, 560 First Avenue, New York, NY 10003, USA.
C R Biol. 2002 Oct;325(10):1039-43. doi: 10.1016/s1631-0691(02)01525-1.
Recent discoveries demonstrating surprising cell plasticity in animals and humans call into question many long held assumptions regarding differentiative potential of adult cells. These assumptions reflect a classical paradigm of cell lineage development projected onto both prenatal development and post-natal maintenance and repair of tissues. The classical paradigm describes unidirectional, hierarchical lineages proceedings step-wise from totipotent or pluripotent stem cells through intermediate, ever more restricted progenitor cells, leading finally to 'terminally differentiated' cells. However, in light of both the recent discoveries and older clinical or experimental findings, we have suggested principles comprising a new paradigm of cell plasticity, summarized here.
近期在动物和人类中发现的惊人细胞可塑性，对许多长期以来关于成体细胞分化潜能的假设提出了质疑。这些假设反映了一种经典的细胞谱系发育模式，该模式被应用于产前发育以及产后组织的维持和修复。经典模式描述了从全能或多能干细胞开始，经过中间的、限制越来越多的祖细胞，以单向、分层的谱系逐步发展，最终形成“终末分化”细胞。然而，鉴于近期的发现以及更早的临床或实验结果，我们提出了一些原则，构成了细胞可塑性的新范式，在此进行总结。
