刀豆氨酸：一种从粉红刀豆中提取的新型胍生物碱，对多巴胺D1受体具有抑制活性。

Canarosine: a new guanidine alkaloid from Canavalia rosea with inhibitory activity on dopamine D1 receptors.

作者信息

Pattamadilok Duangpen, Pengsuparp Thitima, Phummiratch Duangkamol, Ongpipattanakul Boonsri, Meksuriyen Duangdeun, Kawanishi Kazuko, Kaneda Norito, Suttisri Rutt

机构信息

Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):915-8. doi: 10.1080/10286020802181513.

DOI:10.1080/10286020802181513

PMID:19003607

Abstract

A new acyclic guanidine alkaloid, canarosine (1), together with five known compounds, beta-sitosterol (2), stigmasterol (3), daucosterol (4), epi-inositol 6-O-methyl ether (5), and rutin (6), were isolated from the aerial parts of Canavalia rosea. Their structures were established on the basis of their spectroscopic data. In the radioligand receptor binding assay, canarosine (1), at a concentration of 100 microg/ml, caused 91% inhibition of the dopamine D1 receptor binding with an IC50 value of 39.4 +/- 5.8 microM.

摘要

从粉红刀豆的地上部分分离出一种新的无环胍生物碱——刀豆氨酸（1），以及五种已知化合物，即β-谷甾醇（2）、豆甾醇（3）、胡萝卜苷（4）、表肌醇6-O-甲基醚（5）和芦丁（6）。它们的结构是根据光谱数据确定的。在放射性配体受体结合试验中，浓度为100微克/毫升的刀豆氨酸（1）对多巴胺D1受体结合产生91%的抑制作用，IC50值为39.4±5.8微摩尔。