白细胞介素1基因多态性与类风湿关节炎易感性的关联：一项荟萃分析。

Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis.

作者信息

Lee Young Ho, Ji Jong Dae, Song Gwan Gyu

机构信息

Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea.

出版信息

J Rheumatol. 2009 Jan;36(1):12-5. doi: 10.3899/jrheum.080450.

DOI:10.3899/jrheum.080450

PMID:19004046

Abstract

OBJECTIVE

To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA).

METHODS

We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models.

RESULTS

A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio=0.776, 95% confidence interval=0.609-0.988, p=0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA.

CONCLUSION

Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians.

摘要

目的

确定白细胞介素1（IL-1）基因多态性是否与类风湿关节炎（RA）易感性相关。

方法

我们使用固定效应或随机效应模型，对IL-1基因多态性与RA易感性之间的关联进行了荟萃分析。

结果

共使用10个欧洲、7个亚洲和1个拉丁美洲人群样本进行了18项独立比较。对IL-1B +3954 CC基因型的荟萃分析显示，在所有受试者中该基因型与RA相关（比值比=0.776，95%置信区间=0.609 - 0.988，p = 0.040）。在亚洲人中，发现IL-1B +3954与RA之间存在关联。相比之下，在欧洲人群中未发现IL-1B +3954基因多态性与RA易感性之间存在关联。对IL-1B -511和IL-1RN VNTR基因多态性的荟萃分析未发现这些多态性与RA之间存在关联。