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鱿鱼(福布斯氏枪乌贼)视紫红质的分子克隆与一级结构,一种磷脂酶C导向的G蛋白偶联受体

Molecular cloning and primary structure of squid (Loligo forbesi) rhodopsin, a phospholipase C-directed G-protein-linked receptor.

作者信息

Hall M D, Hoon M A, Ryba N J, Pottinger J D, Keen J N, Saibil H R, Findlay J B

机构信息

Department of Biochemistry and Molecular Biology, University of Leeds, U.K.

出版信息

Biochem J. 1991 Feb 15;274 ( Pt 1)(Pt 1):35-40. doi: 10.1042/bj2740035.

Abstract

The sequence of squid (Loligo forbesi) rhodopsin was determined by protein and cDNA sequencing. The protein has close similarity to octopus rhodopsin, having an N-terminal region (residues 1-340) which resembles other guanine-nucleotide-binding protein (G-protein)-linked receptors and a repetitive proline-rich C-terminus (residues 340-452). Comparison of the sequence of squid rhodopsin with those of other members of the G-protein-linked receptor superfamily reveals features which we predict to have both structural and functional importance.

摘要

通过蛋白质和cDNA测序确定了鱿鱼(福布斯氏枪乌贼)视紫红质的序列。该蛋白质与章鱼视紫红质有密切的相似性,具有一个N端区域(第1 - 340位氨基酸残基),它类似于其他鸟嘌呤核苷酸结合蛋白(G蛋白)偶联受体,以及一个富含脯氨酸的重复性C端(第340 - 452位氨基酸残基)。将鱿鱼视紫红质的序列与G蛋白偶联受体超家族的其他成员的序列进行比较,揭示了我们预测具有结构和功能重要性的特征。

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本文引用的文献

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The rhodopsin system of the squid.鱿鱼的视紫红质系统。
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