Kennedy Colleen M, Peterson Lorna B, Galask Rudolph P
Department of Obstetrics and Gynecology, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
J Reprod Med. 2008 Oct;53(10):781-4.
To determine the occurrence of cancer, including vulvovaginal squamous cell carcinoma (SCC), among women after diagnosis of erosive vulvar lichen planus (LP).
Retrospective review of 113 patients diagnosed with erosive vulvar LP over an 8-year period (average follow-up, 5 years).
A diagnosis of cancer was made in 5 women after diagnosis of erosive vulvar LP. Of these, 1 had stage II vulvar SCC after treatment for stage IIB cervical cancer, and 2 with oral LP had subsequent diagnoses of oral or esophageal SCC. The remaining 2 cancer diagnoses included cervical adenocarcinoma in situ and rectal adenocarcinoma.
Of 113 women with erosive vulvar LP, 1 had subsequent development of vulvar SCC. Estimating the risk of SCC among women with vulvar LP is difficult because of the low prevalence of each disorder. Additionally, given the age of the patient and multifocal involvement, association with human papillomavirus was likely. Rather, this cohort exemplifies the need for long-term evaluation in the management of vulvar LP.
确定糜烂性外阴扁平苔藓（LP）诊断后女性中癌症的发生情况，包括外阴阴道鳞状细胞癌（SCC）。
对113例在8年期间被诊断为糜烂性外阴LP的患者进行回顾性研究（平均随访5年）。
5例女性在诊断为糜烂性外阴LP后被诊断出患有癌症。其中，1例在接受IIB期宫颈癌治疗后发生II期外阴SCC，2例患有口腔LP的患者随后被诊断出患有口腔或食管SCC。其余2例癌症诊断包括宫颈原位腺癌和直肠腺癌。
在113例患有糜烂性外阴LP的女性中，1例随后发生了外阴SCC。由于每种疾病的患病率较低，估计外阴LP女性中SCC的风险较为困难。此外，考虑到患者年龄和多灶性受累情况，可能与人乳头瘤病毒有关。相反，该队列体现了对外阴LP管理进行长期评估的必要性。
