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补体受体1：疾病关联及治疗意义。

Complement Receptor 1: disease associations and therapeutic implications.

作者信息

Khera Rohan, Das Nibhriti

机构信息

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.

出版信息

Mol Immunol. 2009 Feb;46(5):761-72. doi: 10.1016/j.molimm.2008.09.026. Epub 2008 Nov 11.

DOI:10.1016/j.molimm.2008.09.026
PMID:19004497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7125513/
Abstract

Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1.

摘要

补体的过度激活是一系列自身免疫性疾病和炎性疾病发病机制中的关键事件。补体受体1（CR1）已成为一种备受关注的分子，有助于深入了解此类疾病的易感性、病理生理学、诊断、预后及治疗。本文综述了目前对CR1的结构、功能、遗传学、疾病关联及治疗意义的综合认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/e29131e34754/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/f4a31150272f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/e69e962a4b6b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/0068208892ce/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/f1b819398da7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/acf138d69efb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/e29131e34754/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/f4a31150272f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/e69e962a4b6b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/0068208892ce/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/f1b819398da7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/acf138d69efb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef3/7125513/e29131e34754/gr6.jpg

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