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补体受体 1 型(CR1/CD35)的结构、遗传多态性、表达和生物学功能。

The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35).

机构信息

College of Animal Science & Veterinary Medicine, Shandong Agriculture University, Tai'an, People's Republic of China.

出版信息

Immunopharmacol Immunotoxicol. 2009;31(4):524-35. doi: 10.3109/08923970902845768.

Abstract

The complement system is comprised of soluble and cell surface associated proteins that recognize exogenous, altered, or potentially harmful endogenous ligands. In recent years, the complement system--particularly component C3 and its receptors--have been demonstrated to be a key link between innate and adaptive immunity. Complement receptor type 1 (CR1), the receptor for C3b/C4b complement peptides, has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. In this review, we wish to briefly bring forth the structure, genetic polymorphisms, expression and biological functions of CR1.

摘要

补体系统由可溶性和细胞表面相关蛋白组成,这些蛋白可识别外源性、改变的或潜在有害的内源性配体。近年来,补体系统-特别是 C3 及其受体-已被证明是先天免疫和适应性免疫之间的关键联系。补体受体 1(CR1)是 C3b/C4b 补体肽的受体,它作为一种分子,在深入了解这些疾病的易感性、病理生理学、诊断、预后和治疗方面具有巨大的意义。在这篇综述中,我们希望简要介绍 CR1 的结构、遗传多态性、表达和生物学功能。

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