Patel Pawan D, Velazquez Jose L, Arora Rohit R
Department of Medicine, The Chicago Medical School, Chicago, IL 60064, United States.
Int J Cardiol. 2009 Feb 20;132(2):157-72. doi: 10.1016/j.ijcard.2008.10.007. Epub 2008 Nov 11.
The journey of atherosclerosis begins with endothelial dysfunction and culminates into its most fearful destination producing ischemia, myocardial infarction and death. The excess cardiovascular disease morbidity and mortality in African-Americans is one of the major public health problems. In this review, we discuss vascular endothelial dysfunction as a key element for excess cardiovascular disease burden in this target population. It can be logical window of future atherosclerotic outcomes, and further efforts should be made to detect it at the earliest in African American individuals even if they are appearing healthy as the therapeutic interventions if instituted early, might prevent the subsequent cardiac events.
动脉粥样硬化的进程始于内皮功能障碍，最终达到其最可怕的结局，即引发缺血、心肌梗死和死亡。非裔美国人中过高的心血管疾病发病率和死亡率是主要的公共卫生问题之一。在本综述中，我们讨论血管内皮功能障碍是该目标人群心血管疾病负担过重的关键因素。它可能是未来动脉粥样硬化结局的合理预测指标，并且应该进一步努力在非裔美国人个体中尽早检测到它，即使他们看起来健康，因为早期进行治疗干预可能会预防随后的心脏事件。
