Romeo C, Seed B
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
Cell. 1991 Mar 8;64(5):1037-46. doi: 10.1016/0092-8674(91)90327-u.
We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.
我们描述了功能性简化的T细胞和Fc受体嵌合体，它们能够引导CD8 + 细胞毒性T淋巴细胞（CTL）特异性识别并裂解表达HIV包膜蛋白的细胞。携带HLA-DR分子的靶细胞不会被携带嵌合体的CTL识别。天然受体具有活性的多种细胞类型表明通过基因手段进行抗病毒干预具有多种可能性。
