Pétain Aurélie, Chatelut Etienne
Institut Claudius-Regaud et EA3035, Université de Toulouse, 20, rue du Pont-Saint-Pierre, 31052 Toulouse cedex, France.
Bull Cancer. 2008 Oct;95(10):895-901. doi: 10.1684/bdc.2008.0720.
The doses of anticancer drugs are usually calculated according to the body surface area. This practice is based on the hypothesis that clearance is proportional to this morphologic parameter. That is rarely true, thus the pharmacodynamic effects (particularly haematological toxicity) are often better correlated with plasma drug concentrations than with doses. The elimination pathways of anticancer drugs will be presented, together with their main sources of interindividual variability. Methods of estimation of renal function will be discussed. These pharmacokinetic concepts allow understanding new alternative methods for individual dosing in oncology.
抗癌药物的剂量通常根据体表面积来计算。这种做法基于清除率与该形态学参数成正比的假设。但这很少是真的，因此药效学效应（尤其是血液学毒性）通常与血浆药物浓度的相关性比与剂量的相关性更好。将介绍抗癌药物的消除途径及其个体间变异性的主要来源。还将讨论肾功能的评估方法。这些药代动力学概念有助于理解肿瘤学中个体给药的新替代方法。
