Lassau Nathalie, Chebil Mohamed, Benatsou Baya, Chami Linda, Roche Alain
Département imagerie, Institut Gustave-Roussy, rue Camille-Desmoulins, 94805 Villejuif, France.
Bull Cancer. 2008 Oct;95(10):989-93. doi: 10.1684/bdc.2008.0721.
Currently, the evaluation of targeted treatments by functional imaging in oncology is a main goal. Several techniques as Dynamic Contrast Enhanced-MRI, CT-perfusion or Dynamic Contrast Enhanced-US are proposed. The blood flow perfusing the tumor, the blood volume corresponding to the percentage of vessels of total tumor or the diffusion of contrast agent are parameters calculated from the acquisition of time intensity curves during several minutes (TIC). Blood flow, blood volume and mean transit time could be calculated by DCE-US, DCE-MRI and CT-perfusion. But the capillary permeability and the interstitial volume could be evaluated only with DCE-MRI and CT-perfusion because US contrast agent is strictly intravascular. These functional imaging techniques allow predicting earlier the clinical response to targeted treatments before the modification of tumoral volume evaluated according to RECIST criteria.
目前，通过功能成像评估肿瘤学中的靶向治疗是一个主要目标。人们提出了几种技术，如动态对比增强磁共振成像（Dynamic Contrast Enhanced-MRI）、CT灌注成像或动态对比增强超声检查（Dynamic Contrast Enhanced-US）。灌注肿瘤的血流量、对应于肿瘤总血管百分比的血容量或造影剂的扩散是通过在几分钟内采集时间-强度曲线（TIC）计算得出的参数。血流量、血容量和平均通过时间可以通过动态对比增强超声检查、动态对比增强磁共振成像和CT灌注成像来计算。但由于超声造影剂严格限制在血管内，只有动态对比增强磁共振成像和CT灌注成像能够评估毛细血管通透性和组织间隙容积。这些功能成像技术能够在根据实体瘤疗效评价标准（RECIST）评估肿瘤体积改变之前，更早地预测靶向治疗的临床反应。
