Ron-El R, Herman A, Golan A, Nachum H, Soffer Y, Caspi E
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
Fertil Steril. 1991 Mar;55(3):574-8.
A prospective study was designed to compare cycles stimulated by human menopausal gonadotropin (hMG) (group A) with cycles pretreated with gonadotropin-releasing hormone agonist causing pituitary desensitization followed by hMG stimulation (group B). Three hundred two cycles were randomly allocated to each group. Cancellation rate was 27.2% in group A compared with only 3.3% in group B. Significantly less hMG ampules for a shorter period were needed in group A patients. Lower estradiol and higher luteinizing hormone levels were detected in the hMG group. Patients in group B yielded significantly more oocytes and more embryos per retrieval. A significantly higher pregnancy rate per cycle was obtained in group B (27%) as compared with that of group A (13%). Moderate and severe ovarian hyperstimulation syndrome was significantly more frequent in group B than in group A.
一项前瞻性研究旨在比较人绝经期促性腺激素（hMG）刺激的周期（A组）与先用促性腺激素释放激素激动剂使垂体脱敏然后进行hMG刺激的周期（B组）。每组随机分配302个周期。A组的取消率为27.2%，而B组仅为3.3%。A组患者所需的hMG安瓿显著较少，使用时间也较短。在hMG组中检测到较低的雌二醇水平和较高的黄体生成素水平。B组患者每次取卵产生的卵母细胞和胚胎明显更多。与A组（13%）相比，B组每个周期的妊娠率显著更高（27%）。B组中重度卵巢过度刺激综合征的发生率明显高于A组。
