极低的精子计数会影响卵胞浆内单精子注射的结果。
Very low sperm count affects the result of intracytoplasmic sperm injection.
作者信息
Strassburger D, Friedler S, Raziel A, Schachter M, Kasterstein E, Ron-el R
机构信息
IVF and Infertility Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
出版信息
J Assist Reprod Genet. 2000 Sep;17(8):431-6. doi: 10.1023/a:1009413201849.
PURPOSE
The aim was to examine the influence of extremely low sperm count on intracytoplasmic sperm injection (ICSI) outcome.
METHODS
Over 1000 consecutive unselected ICSI cycles were divided into four groups according to sperm concentration of their patients: A, cryptozoospermia, 107 patients; B, sperm concentration of < or = 1 x 10(4), 146 patients; C, sperm count of 1 x 10(4)-1 x 10(5), 135 patients; and concentration of > 1 x 10(5) and < 10 x 10(6)/ml (control group), 688 patients.
RESULTS
A significant decrease in pregnancy rate was noticed in the cryptozoospermic group in comparison to the control group (20% vs. 31%). Fertilization rate in group A was significantly lower in comparison to all other groups, respectively (46% vs. 52%, 54%, 61%). Embryo quality was inferior in group A in comparison to the control group. A higher yet not statistically significant abortion rate was observed in the cryptozoospermic group (as well as in group C) (30%, 27%) compared to the control group (15%).
CONCLUSIONS
It seems that an extremely low sperm count has a negative effect on the outcome of ICSI. Nevertheless patients with cryptozoospermia should not be offered ICSI treatment with the ejaculated sperm before karyotype is established.
目的
本研究旨在探讨极低精子计数对卵胞浆内单精子注射（ICSI）结局的影响。
方法
超过1000例未经筛选的连续ICSI周期根据患者精子浓度分为四组：A组，隐匿精子症，107例患者；B组，精子浓度≤1×10⁴，146例患者；C组，精子计数为1×10⁴ - 1×10⁵，135例患者；以及浓度＞1×10⁵且＜10×10⁶/ml（对照组），688例患者。
结果
与对照组相比，隐匿精子症组的妊娠率显著降低（20%对31%）。A组的受精率分别显著低于所有其他组（46%对52%、54%、61%）。与对照组相比，A组的胚胎质量较差。隐匿精子症组（以及C组）的流产率高于对照组（分别为30%、27%对15%），但差异无统计学意义。
结论
极低精子计数似乎对ICSI结局有负面影响。然而，在确定核型之前，不应为隐匿精子症患者提供经射精精子的ICSI治疗。
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