Ballesteros F, Alobid I, Tassies D, Reverter J C, Scharf R E, Guilemany J M, Bernal-Sprekelsen M
Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Clínic de Barcelona, ES-08036 Barcelona, Spain.
Audiol Neurootol. 2009;14(3):139-45. doi: 10.1159/000171475. Epub 2008 Nov 13.
Sudden sensorineural hearing loss (SSHL) has been proposed as a symptom of underlying vascular problems. The purpose of this work is to evaluate the genetic and acquired risk factors.
Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated. Additional assessments of personal and familial history risk factors for vascular disorders were performed in each patient.
Thrombophilia studies did not demonstrate statistically relevant differences between the patients and control group. However, lipidemia profile and directed personal and familial histories showed positive trends for SSHL.
The lack of clear relationships between SSHL and other vascular risk factors suggests multicausality as a predominant disease profile. Although preliminary results point at a vascular involvement in SSHL, a long-term prospective study is necessary to demonstrate that SSHL represents an early vascular symptom.
突发性感音神经性听力损失（SSHL）被认为是潜在血管问题的一种症状。本研究的目的是评估遗传和后天危险因素。
对99名患者进行检测，以评估与血栓形成倾向相关的常见多态性（凝血酶原和因子V莱顿）的存在情况，从而评估遗传危险因素，并对一些经典的与血管疾病相关的参数（心血管事件、脑卒中和抗磷脂综合征）进行评估。对每位患者还进行了血管疾病个人和家族史危险因素的额外评估。
血栓形成倾向研究未显示患者与对照组之间存在统计学上的显著差异。然而，血脂谱以及针对性的个人和家族史显示出与SSHL呈正相关趋势。
SSHL与其他血管危险因素之间缺乏明确关系，这表明多因素病因是该病的主要特征。尽管初步结果表明血管因素与SSHL有关，但仍需要长期的前瞻性研究来证明SSHL是一种早期血管症状。
