Niu Xun, Chen Yuzhang, Zhong Yi, Xiao Xiyue
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Eur Arch Otorhinolaryngol. 2023 May;280(5):2091-2097. doi: 10.1007/s00405-023-07829-w. Epub 2023 Jan 19.
There was disagreement over the association between serum/plasma homocysteine (HCY) levels and sudden sensorineural hearing loss (SSNHL). Through the use of a meta-analysis, this study aims to determine whether there is a significant difference in serum homocysteine levels between the SSNHL group and the control group.
The Cochrane Library, EMBASE, and PubMed databases were all thoroughly searched. The two independent reviewers thoroughly examined the initially searched articles. The data results were calculated by standard mean difference (SMD) or odds ratios (OR). Review Manager (version 5.3) was applied to statistical data.
There were 766 participants in the 6 trials with continuous outcomes that were part of the meta-analysis A. In addition, meta-analysis B, which included 961 people, contained a total of 3 studies with dichotomous results.
Both meta-analyses revealed the same conclusion that serum/plasma HCY levels in the SSNHL patients are higher than those in the controls (SMD 0.41, 95 % confidence interval (CI) 0.11 to 0.72, P < 0.01; OR 3.27, 95 % CI 2.16 to 4.94, P < 0.01).
This study demonstrated that the SSNHL patients' serum/plasma HCY levels were greater than those of the control group.
血清/血浆同型半胱氨酸（HCY）水平与突发性感音神经性听力损失（SSNHL）之间的关联存在争议。本研究旨在通过荟萃分析确定SSNHL组与对照组之间血清同型半胱氨酸水平是否存在显著差异。
全面检索了Cochrane图书馆、EMBASE和PubMed数据库。两名独立评审员对最初检索到的文章进行了全面审查。数据结果通过标准平均差（SMD）或比值比（OR）计算。使用Review Manager（5.3版）进行统计数据处理。
荟萃分析A中包含6项具有连续结果的试验，共有766名参与者。此外，荟萃分析B包含961人，共有3项具有二分结果的研究。
两项荟萃分析均得出相同结论，即SSNHL患者的血清/血浆HCY水平高于对照组（SMD 0.41，95%置信区间（CI）0.11至0.72，P<0.01；OR 3.27，95%CI 2.16至4.94，P<0.01）。
本研究表明，SSNHL患者的血清/血浆HCY水平高于对照组。
