Santora Rachel J, McKinley Bruce A, Moore Frederick A
The Methodist Hospital-Houston/Weill Medical College of Cornell University, Houston, Texas, USA.
Curr Opin Crit Care. 2008 Dec;14(6):679-84. doi: 10.1097/MCC.0b013e328319654b.
To review what we learned through implementation of computerized decision support for ICU resuscitation of major torso trauma patients who arrive in shock.
Overall, these patients respond well to preload-directed goal-orientated ICU resuscitation; however, the subset of patients destined to develop abdominal compartment syndrome do not respond well. In fact, this strategy precipitates the full-blown syndrome that is a new iatrogenic variant of multiple organ failure. The clinical trajectory of abdominal compartment syndrome starts early after emergency department admission and its course is fairly well defined by the time patients reach the ICU. It occurs in patients who arrive with severe bleeding that is not readily controlled. These patients require a very different emergency department management strategy. Hemorrhage control is paramount. Alternative massive transfusion protocols should be used with an emphasis on hemostasis and avoidance of excessive isotonic crystalloids. Finally, near-infrared spectroscopy that measures tissue hemoglobin saturation in skeletal muscle (StO2) is good at identifying high-risk patients. A falling StO2 in the setting of ongoing resuscitation is a harbinger of death from early exsanguination and multiple organ failure.
Fundamental changes are needed in the care of trauma patients who arrive in shock and require a massive transfusion.
回顾通过对休克状态下到达的严重躯干创伤患者实施重症监护病房(ICU)复苏的计算机决策支持,我们学到了什么。
总体而言,这些患者对基于前负荷导向的目标导向性ICU复苏反应良好;然而,注定会发生腹腔间隔室综合征的患者亚组反应不佳。事实上,这种策略会引发全面综合征,这是多器官功能衰竭的一种新的医源性变体。腹腔间隔室综合征的临床轨迹在急诊科入院后早期就开始了,到患者进入ICU时其病程已相当明确。它发生在那些严重出血且难以立即控制的患者身上。这些患者需要一种截然不同的急诊科管理策略。控制出血至关重要。应采用替代大量输血方案,重点是止血并避免过量使用等渗晶体液。最后,测量骨骼肌组织血红蛋白饱和度(StO2)的近红外光谱法擅长识别高危患者。在持续复苏过程中StO2下降是早期失血和多器官功能衰竭导致死亡的先兆。
对于休克状态下到达且需要大量输血的创伤患者的护理,需要进行根本性变革。