Khalil Hisham Saleh
Plymouth Hospitals NHS Trust, UK bPeninsula College of Medicine and Dentistry, Plymouth, UK.
Curr Opin Otolaryngol Head Neck Surg. 2008 Dec;16(6):516-20. doi: 10.1097/MOO.0b013e328313bb7f.
Globus pharyngeus is a common disorder that accounts for approximately 4% of new ear, nose and throat referrals. The presenting symptoms are a cause of anxiety for patients and clinicians alike. There is a great deal of controversy surrounding the diagnosis and treatment of this disorder. This article discusses current trends in the management of this condition.
Globus symptoms are associated with proximal reflux. Globus symptoms in patients with laryngopharyngeal reflux treated with proton pump inhibitor resolve more slowly than classic reflux symptoms in patients with gastroesophageal reflux. Thyroid surgery may help improve globus symptoms in patients with goiter. Short-tem results suggest that speech therapy is effective in relieving symptoms of globus.
The cause of globus symptoms remains an enigma. The diagnosis of this symptom complex is essentially clinical. There is a limited role for investigations in patients with atypical symptoms. Treatment remains controversial and includes reassurance, speech therapy and proton pump inhibitors in patients with laryngopharyngeal reflux.
咽异感症是一种常见疾病，约占耳鼻喉科新转诊患者的4%。其出现的症状令患者和临床医生都感到焦虑。围绕这种疾病的诊断和治疗存在诸多争议。本文讨论了该病当前的治疗趋势。
咽异感症症状与近端反流有关。用质子泵抑制剂治疗的喉咽反流患者的咽异感症症状比胃食管反流患者的典型反流症状缓解得更慢。甲状腺手术可能有助于改善甲状腺肿患者的咽异感症症状。短期结果表明言语治疗对缓解咽异感症症状有效。
咽异感症症状的病因仍是个谜。这种症状复合体的诊断本质上是临床诊断。对于非典型症状患者，检查的作用有限。治疗仍存在争议，包括给予安慰、言语治疗以及对喉咽反流患者使用质子泵抑制剂。
