γH2AX与癌症
GammaH2AX and cancer.
作者信息
Bonner William M, Redon Christophe E, Dickey Jennifer S, Nakamura Asako J, Sedelnikova Olga A, Solier Stéphanie, Pommier Yves
机构信息
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nat Rev Cancer. 2008 Dec;8(12):957-67. doi: 10.1038/nrc2523. Epub 2008 Nov 13.
Abstract
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
摘要
组蛋白H2AX在其羧基末端四个残基处的丝氨酸上发生磷酸化（产生γH2AX）是DNA双链断裂（DSB）的敏感标志物。DSB可能会导致癌症，但矛盾的是，它也被用于杀死癌细胞。利用γH2AX检测来确定DSB诱导的程度，可能有助于检测癌前细胞、对癌症进行分期、监测癌症治疗的效果以及开发新型抗癌药物。
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