铑催化手性链烯基三氟硼酸盐的共轭加成：隐士酰胺A和B的对映选择性合成。
Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B.
作者信息
Frost Christopher G, Penrose Stephen D, Gleave Robert
机构信息
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
出版信息
Org Biomol Chem. 2008 Dec 7;6(23):4340-7. doi: 10.1039/b812897a. Epub 2008 Oct 18.
DOI:10.1039/b812897a
PMID:19005593
Abstract
The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt.
摘要
利用铑催化的共轭加成反应，通过烯基三氟硼酸盐在一步反应中引入侧链和手性信息，实现了hermitamides A和B的简洁对映选择性合成。
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