Dispersyn Garance, Pain Laure, Challet Etienne, Touitou Yvan
Facult de Médecine Pierre et Marie Curie, Service de Biochimie Médicale et Biologie Moléculaire, INSERM U713, Paris, France.
Chronobiol Int. 2008 Nov;25(6):835-50. doi: 10.1080/07420520802551386.
Disruptions of circadian and biological rhythms as well as general anesthesia can induce sleep disorders, resulting in an increase in sleepiness and drowsiness and a decrease in vigilance. It has been previously shown that circadian time can influence the pharmacologic sensitivity and the duration of action of general anesthetics. Studies on interactions between general anesthesia and circadian rhythms are few, but all of them suggest an important role of general anesthetics on circadian rhythms. General anesthesia is a particular wake-sleep state that could potentially alter circadian rhythms on the days following anesthesia. The aim of this review is to discuss the various effects of general anesthesia on animal and human circadian time structure. This topic is highly relevant to clinicians, especially those involved in that field of ambulatory practice responsible for post-operative patient care, including patient recovery and fatigue.
昼夜节律和生物节律的紊乱以及全身麻醉均可诱发睡眠障碍，导致嗜睡和困倦增加，警觉性降低。先前已有研究表明，昼夜时间可影响全身麻醉药的药理敏感性和作用持续时间。关于全身麻醉与昼夜节律之间相互作用的研究较少，但所有研究均表明全身麻醉药在昼夜节律中起重要作用。全身麻醉是一种特殊的清醒-睡眠状态，可能会在麻醉后的几天内改变昼夜节律。本综述的目的是探讨全身麻醉对动物和人类昼夜时间结构的各种影响。这一主题与临床医生高度相关，尤其是那些从事门诊实践领域、负责术后患者护理（包括患者康复和疲劳）的医生。
