[儿童和青少年及其父母的肥胖问题。来自多中心APS数据的患者与其父母及兄弟姐妹之间标准化体重指数的相关性]
[Obesity in children and adolescents and their parents. Correlation of standardized body mass index between patients, their parents and siblings from the multicentre APS data].
作者信息
Röbl M, Knerr I, Keller K M, Jaeschke R, Hoffmeister U, Reinehr T, Holl R W
机构信息
Pädiatrie 2, Universitäts-Kinderklinik Göttingen, Göttingen.
出版信息
Dtsch Med Wochenschr. 2008 Nov;133(47):2448-53. doi: 10.1055/s-0028-1100937. Epub 2008 Nov 12.
BACKGROUND
Obesity in children and adolescents is moving into the focus of public interest. Genetic as well as environmental factors are important in the etiology of obesity. The aim of this multicentre study was to correlate the weight of overweight or obese children and adolescents with that of their parents and siblings.
PATIENTS AND METHODS
Anthropometric and other data - comorbidities, various influencing factors and treatment - were collected from the adiposity data acquisition system for prospective surveillance (APS). Currently 125 medical centers and pediatric care clinics in Germany, Austria and Switzerland use the APS documentation. Until February 2008 data on a total of 37,062 children and adolescents had been collected.
RESULTS
Data to calculate the Body Mass Index (BMI) were obtained from both parents of 11,074 (29,9%) children and adolescents. The mean BMI Standard Deviation Score (SDS) of these children and adolescents was 2.46. Their mean age was 11.9 years; 46% were males. The mean BMI-SDS of these children and adolescents correlated significantly with the BMI-SDS of both the mother (r=0.29 [Spearman's rank correlation coefficient]) and the father (r=018, both p<0.0001). The correlation with the father's BMI was closer in adolescents (15-20 years, r=0.20) than in young children (<10 years: r=0.12). The correlation with the mother's BMI was independent of age. A multivariate model including the BMI of the parents as well as age and sex of the children and adolescents explained 10.0% of the variance. Significant influencing factors were BMI of the mother, sex and the relationship between BMI of mother, age and sex. Data for the BMI of siblings were available of 3,933 (10.6 %) children and adolescents. The correlation of the BMI of the children and adolescents with that of their siblings was +0.17 (p<0.0001). This correlation was highest in adolescence (<10 years.: r=0.17, 15-20 years.: r=0.24, both p<0.0001).
CONCLUSION
The patient's weight correlated more strongly with the mother's than the father's weight or that of the siblings.
背景
儿童和青少年肥胖问题正成为公众关注的焦点。遗传因素以及环境因素在肥胖病因中都很重要。这项多中心研究的目的是将超重或肥胖儿童及青少年的体重与其父母及兄弟姐妹的体重进行关联分析。
患者与方法
人体测量数据以及其他数据——合并症、各种影响因素和治疗情况——均从用于前瞻性监测的肥胖数据采集系统（APS）中收集。目前德国、奥地利和瑞士的125家医疗中心及儿科诊所使用该APS文档。截至2008年2月，总共收集了37062名儿童和青少年的数据。
结果
获取了11074名（29.9%）儿童和青少年父母双方用于计算体重指数（BMI）的数据。这些儿童和青少年的平均BMI标准差得分（SDS）为2.46。他们的平均年龄为11.9岁；46%为男性。这些儿童和青少年的平均BMI-SDS与母亲（r = 0.29[斯皮尔曼等级相关系数]）和父亲（r = 0.18，两者p < 0.0001）的BMI-SDS均显著相关。与父亲BMI的相关性在青少年（15 - 20岁，r = 0.20）中比在幼儿（<10岁：r = 0.12）中更紧密。与母亲BMI的相关性与年龄无关。一个包含父母BMI以及儿童和青少年年龄与性别的多变量模型解释了10.0%的方差。显著影响因素为母亲的BMI、性别以及母亲BMI、年龄和性别之间的关系。获取了3933名（10.6%）儿童和青少年兄弟姐妹的BMI数据。儿童和青少年的BMI与其兄弟姐妹的BMI的相关性为 +0.17（p < 0.0001）。这种相关性在青少年期最高（<10岁：r = 0.17，15 - 20岁：r = 0.24，两者p < 0.0001）。
结论
患者的体重与其母亲体重的相关性比与其父亲体重或兄弟姐妹体重的相关性更强。
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