一锅法去对称氢甲酰化/羰基烯环化反应：高官能化环己醇的简便合成方法。
One-pot desymmetrizing hydroformylation/carbonyl ene cyclization process: straightforward access to highly functionalized cyclohexanols.
机构信息
Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, D-79104 Freiburg, Germany.
出版信息
Org Lett. 2008 Dec 4;10(23):5321-4. doi: 10.1021/ol8016148.
PMID:19006319
Abstract
Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.
摘要
通过从简单的双烯丙基仲醇一锅法去对称氢甲酰化/羰基烯环化反应，快速获得高官能化的亚烷基环己醇。本文对羰基烯反应的机理进行了深入研究，强调了超共轭取代基效应的重要性。
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