Sichel F, Bar E, Gauduchon P, Malas J P, Benard J, Le Talaer J Y
Centre régional de Lutte contre le Cancer F. Baclesse, Caen.
C R Acad Sci III. 1991;312(1):19-24.
A cell line, IGROV1, originating from a human ovarian cancer, releases a galactosyltransferase activity in its culture medium during proliferation. The proliferating IGROV1 cells appear as two populations: some cells grow in floating clusters whereas the greater part of them adhere to the culture substrate. The study of galactose transfer by intact cells onto an exogenous glycoprotein acceptor (ovomucoid) shows the presence of surface-associated galactosyltransferase onto the two cellular sub-populations. Opposite to intracellular activity, surface-associated and released galactosyltransferase activities depend on cellular adhesion and proliferation.
一种源自人类卵巢癌的细胞系IGROV1，在增殖过程中会在其培养基中释放半乳糖基转移酶活性。增殖的IGROV1细胞表现为两个群体：一些细胞以漂浮的细胞团形式生长，而其中大部分细胞则附着在培养底物上。对完整细胞将半乳糖转移到外源性糖蛋白受体（卵类粘蛋白）上的研究表明，在这两个细胞亚群上均存在与表面相关的半乳糖基转移酶。与细胞内活性相反，与表面相关的和释放的半乳糖基转移酶活性取决于细胞粘附和增殖。
