Toll样受体作为囊性纤维化的治疗靶点。
Toll-like receptors as therapeutic targets in cystic fibrosis.
作者信息
Greene Catherine M, Branagan Peter, McElvaney Noel G
机构信息
Beaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland.
出版信息
Expert Opin Ther Targets. 2008 Dec;12(12):1481-95. doi: 10.1517/14728220802515293.
BACKGROUND
Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs.
OBJECTIVE/METHODS: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF.
RESULTS/CONCLUSION: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.
背景
Toll样受体（TLRs）是模式识别受体，通过识别和响应微生物因子及内源性危险信号中的保守分子模式，在先天免疫反应中充当第一道防线。受囊性纤维化（CF）影响的气道是一个潜在富含TLR激动剂的环境，CF气道上皮细胞中明显的慢性炎症表型可能在很大程度上归因于TLRs的激活。
目的/方法：通过靶向TLRs来研究开发CF新疗法的前景。我们概述了TLRs的表达和功能，并探讨天然和合成TLR抑制剂对CF的治疗潜力。
结果/结论：调节TLRs对CF的炎症性肺部表现具有治疗潜力。
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