中国仓鼠细胞突变体V-H4与范可尼贫血（互补组A）同源。

The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A).

作者信息

Arwert F, Rooimans M A, Westerveld A, Simons J W, Zdzienicka M Z

机构信息

Department of Human Genetics, Medical Faculty, Free University, Amsterdam, The Netherlands.

出版信息

Cytogenet Cell Genet. 1991;56(1):23-6. doi: 10.1159/000133038.

DOI:10.1159/000133038

PMID:1900747

Abstract

V-H4, a mitomycin C (MMC)-sensitive Chinese hamster cell mutant, is phenotypically very similar to Fanconi anemia (FA) cells. Genetic complementation analysis shows that V-H4 belongs to the same complementation group as FA group A cells. Proliferating hybrid cell lines obtained after fusion of V-H4 with normal or FA group B cells show an increased resistance to MMC. Absence of complementation was noted in V-H4 x FA group A hybrid cell lines. This was shown not to be due to the absence of a specific human chromosome. The V-H4 mutant represents the first rodent mutant that is genotypically similar to FA complementation group A cells.

摘要

V-H4是一种对丝裂霉素C（MMC）敏感的中国仓鼠细胞突变体，其表型与范可尼贫血（FA）细胞非常相似。遗传互补分析表明，V-H4与FA A组细胞属于同一互补群。V-H4与正常或FA B组细胞融合后获得的增殖杂交细胞系对MMC的抗性增强。在V-H4×FA A组杂交细胞系中未观察到互补现象。结果表明，这并非由于特定人类染色体的缺失所致。V-H4突变体是第一个在基因型上与FA A组互补群细胞相似的啮齿动物突变体。