Depression of multinucleation by interferon in simian virus 40-transformed cells treated with cytochalasin-B.

Multinucleation of simian virus 40-transformed mouse cells (mKS-A TU-7), which was induced by Cytochalasin-B, was depressed by the addition of crude interferon or by poly (riboinosinic)-poly(ribocytidylic) acid. In the absence of Cytochalasin-B, growth of the cells was not inhibited by interferon. Possible mechanism of this phenomenon is discussed.