Zelante Teresa, Fallarino Francesca, Bistoni Francesco, Puccetti Paolo, Romani Luigina
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.
Microbes Infect. 2009 Jan;11(1):133-41. doi: 10.1016/j.micinf.2008.10.007. Epub 2008 Oct 25.
Initially recognized in infection because of antimicrobial activity ('tryptophan starvation'), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions.
吲哚胺2,3-双加氧酶（IDO）最初是因其抗菌活性（“色氨酸饥饿”）在感染中被识别出来的，它广泛参与宿主免疫稳态，甚至参与建立共生关系或慢性感染的微生物的免疫逃逸。本综述探讨了一些最新研究发现，这些发现可能使IDO在哺乳动物宿主/微生物相互作用中获得“多面手”的声誉。
