家族性偏瘫性偏头痛中的FHM3比FHM1和FHM2更不易发生突变。

FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.

作者信息

Wiwanitkit Viroj

机构信息

Wiwanitkit House, Bangkhae, Bangkok, 10160, Thailand.

出版信息

J Neurol Sci. 2009 Feb 15;277(1-2):76-9. doi: 10.1016/j.jns.2008.10.012. Epub 2008 Nov 13.

DOI:10.1016/j.jns.2008.10.012

PMID:19007941

Abstract

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions within the studied FHM. Of interest, the author detected that FHM3 is a high resistant molecule when compared to FHM1 and FHM2.

摘要

家族性偏瘫性偏头痛（FHM）是偏头痛伴先兆和短暂性偏瘫的一种罕见亚型。据报道，CACNA1A（FHM1）基因、ATP1A2（FHM2）基因和SCN1A（FHM3）基因与FHM相关。在此，进行了一项生物信息学分析，以研究上述三种分子氨基酸序列内的突变风险位点。在这项研究中，作者能够识别出所研究的FHM内许多易于发生突变的位点。有趣的是，作者检测到与FHM1和FHM2相比，FHM3是一种高抗性分子。