Bosch-Barrera Joaquim, Montero Alberto, López-Picazo José María, García-Foncillas Jesús, Ferrer Marta, Yuste José Ramón, Gil-Bazo Ignacio
Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
Lung Cancer. 2009 Apr;64(1):124-6. doi: 10.1016/j.lungcan.2008.09.013. Epub 2008 Nov 13.
Pemetrexed is a multitargeted antifolate approved for the second-line treatment of locally advanced or metastatic non-small cell lung cancer. The combination of pemetrexed with gemcitabine has been studied in several clinical trials showing a promising antitumor activity with a mild toxicity profile. We present the case of a patient who experienced fever, arthralgia, skin rash and high serum ferritin levels after first cycle of this chemotherapy combination, compatible with an adult onset Still's disease. This adverse event has not been previously reported.
培美曲塞是一种多靶点抗叶酸药物，被批准用于局部晚期或转移性非小细胞肺癌的二线治疗。培美曲塞与吉西他滨联合用药已在多项临床试验中进行了研究，显示出有前景的抗肿瘤活性且毒性较轻。我们报告了一例患者，在接受这种化疗联合方案的第一个周期后出现发热、关节痛、皮疹和血清铁蛋白水平升高，符合成人斯蒂尔病。此前尚未报道过这种不良事件。
