Nazir F S, Petre I, Dewey H M
Department of Neurology, Austin Health, Heidelberg, Victoria 3084, Australia.
J Clin Neurosci. 2009 Jan;16(1):21-5. doi: 10.1016/j.jocn.2008.02.004. Epub 2008 Nov 12.
Recombinant tissue plasminogen activator (rtPA) reduces the combined endpoint of death and disability if given within three hours of onset of ischaemic stroke. However few patients receive rtPA, with delays in in-hospital evaluation and treatment being key barriers to therapy. The Austin Hospital Acute Stroke Team (AST) was introduced with the aim of improving the speed of assessment and management of acute stroke patients presenting to the emergency department. We sought to assess the effect of the AST on number of eligible patients receiving rtPA and assessment times within our already active stroke service. Data were obtained prospectively for all AST calls during the period from 17 January 2005--31 December 2005. Information recorded included: demographics, time of call, clinical features, diagnosis and any treatment with rtPA. Information prospectively acquired from patients receiving stroke thrombolysis the previous year was also analysed. There were 663 stroke unit admissions and 224 AST calls during the study period. 53% of calls occurred within working hours and 68% had a final diagnosis of stroke. Twenty-seven patients received treatment with rtPA (12% of calls), whereas only ten patients received rtPA in 2004. The most common reason for not treating was mild or rapidly resolving deficit. Onset-needle time and door-needle times significantly improved following introduction of the AST. Thus, we conclude that the introduction of the AST emergency call system has increased the number of eligible patients receiving rtPA. Improved onset-needle and door-needle times are achievable by this team approach.
重组组织型纤溶酶原激活剂(rtPA)在缺血性中风发作三小时内使用可降低死亡和残疾的综合终点。然而,很少有患者接受rtPA治疗,住院评估和治疗的延迟是治疗的关键障碍。奥斯汀医院急性中风团队(AST)的引入旨在提高对急诊科急性中风患者的评估和管理速度。我们试图评估AST对接受rtPA治疗的符合条件患者数量以及在我们已经很活跃的中风服务中的评估时间的影响。前瞻性收集了2005年1月17日至2005年12月31日期间所有AST呼叫的数据。记录的信息包括:人口统计学、呼叫时间、临床特征、诊断以及任何rtPA治疗情况。还分析了前一年接受中风溶栓治疗患者前瞻性获取的信息。研究期间有663例中风单元入院病例和224次AST呼叫。53%的呼叫发生在工作时间内,68%最终诊断为中风。27例患者接受了rtPA治疗(占呼叫的12%),而2004年只有10例患者接受rtPA治疗。未治疗的最常见原因是症状轻微或迅速缓解。引入AST后,发病至穿刺时间和入院至穿刺时间显著改善。因此,我们得出结论,AST紧急呼叫系统的引入增加了接受rtPA治疗的符合条件患者数量。通过这种团队方法可以实现更好的发病至穿刺和入院至穿刺时间。