Churcher Thomas S, Basáñez María-Gloria
Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
Trends Parasitol. 2009 Jan;25(1):11-7. doi: 10.1016/j.pt.2008.09.011. Epub 2008 Nov 12.
The large-scale use of mass drug administration in human helminthiases control has raised awareness that anthelmintic resistance could develop. This has motivated an increasing number of studies to investigate changes in genetic structure of parasite populations undergoing treatment. For these studies to reflect accurately the current situation, parasitologists need to consider the sampling schemes they employ. In this article, we use mathematical models to discuss issues such as which hosts to examine, on which parasite life stage(s) to focus, and when after treatment to sample to quantify the presence and frequency of genetic markers of treatment-induced selection or drug resistance.
在人类蠕虫病防治中大规模使用群体药物给药已提高了人们对驱虫抗药性可能产生的认识。这促使越来越多的研究去调查接受治疗的寄生虫种群遗传结构的变化。为使这些研究能准确反映当前情况，寄生虫学家需要考虑他们所采用的抽样方案。在本文中，我们使用数学模型来讨论诸如检查哪些宿主、关注寄生虫的哪些生活阶段以及治疗后何时进行抽样以量化治疗诱导选择或抗药性的遗传标记的存在和频率等问题。
