Nagao Tomonori, Meguro Shinichi, Hase Tadashi, Otsuka Kazuhiro, Komikado Masanori, Tokimitsu Ichiro, Yamamoto Takashi, Yamamoto Kunio
Health Care Food Research Laboratories, Kao Corporation, Tokyo, Japan.
Obesity (Silver Spring). 2009 Feb;17(2):310-7. doi: 10.1038/oby.2008.505. Epub 2008 Nov 13.
We investigated the effects of continuous ingestion of a catechin-rich beverage in patients with type 2 diabetes who were not receiving insulin (Ins) therapy in a double-blind controlled study. The participants ingested green tea containing either 582.8 mg of catechins (catechin group; n = 23) or 96.3 mg of catechins (control group; n = 20) per day for 12 weeks. At week 12, the decrease in waist circumference was significantly greater in the catechin group than in the control group. Adiponectin, which is negatively correlated with visceral adiposity, increased significantly only in the catechin group. Although the increase in Ins at week 12 was significantly greater in the catechin group than in the control group, no apparent difference was noted between the two groups in glucose and hemoglobin A(1c). In patients treated with insulinotropic agents, the increase in Ins at week 12 was significantly greater in the catechin group than in the control group. This significant increase in Ins levels was observed only in the catechin group. In the catechin group receiving other treatments, Ins levels remained unchanged. In addition, in patients treated with insulinotropic agents, the decrease in hemoglobin A(1c) at week 12 was significantly greater in the catechin group than in the control group. These results suggest that a catechin-rich beverage might have several therapeutic uses: in the prevention of obesity; in the recovery of Ins-secretory ability; and, as a way to maintain low hemoglobin A(1c) levels in type 2 diabetic patients who do not yet require Ins therapy.
在一项双盲对照研究中，我们调查了持续摄入富含儿茶素的饮料对未接受胰岛素（Ins）治疗的2型糖尿病患者的影响。参与者连续12周每天摄入含有582.8毫克儿茶素的绿茶（儿茶素组；n = 23）或含有96.3毫克儿茶素的绿茶（对照组；n = 20）。在第12周时，儿茶素组的腰围减少幅度显著大于对照组。脂联素与内脏肥胖呈负相关，仅在儿茶素组中显著增加。虽然儿茶素组在第12周时Ins的增加幅度显著大于对照组，但两组在血糖和糖化血红蛋白A1c方面没有明显差异。在接受促胰岛素分泌剂治疗的患者中，儿茶素组在第12周时Ins的增加幅度显著大于对照组。仅在儿茶素组中观察到Ins水平的这种显著增加。在接受其他治疗的儿茶素组中，Ins水平保持不变。此外，在接受促胰岛素分泌剂治疗的患者中，儿茶素组在第12周时糖化血红蛋白A1c的降低幅度显著大于对照组。这些结果表明，富含儿茶素的饮料可能有多种治疗用途：预防肥胖；恢复Ins分泌能力；以及作为尚未需要Ins治疗的2型糖尿病患者维持低糖化血红蛋白A1c水平的一种方法。
