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1
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. doi: 10.1073/pnas.0808470105. Epub 2008 Oct 7.
2
The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5. doi: 10.1073/pnas.0808070105. Epub 2008 Oct 6.
3
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9. doi: 10.1073/pnas.0808069105. Epub 2008 Oct 3.
4
Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation.
J Immunol. 2008 Oct 15;181(8):5225-32. doi: 10.4049/jimmunol.181.8.5225.
5
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007.
6
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity. 2008 Sep 19;29(3):438-50. doi: 10.1016/j.immuni.2008.06.018.
7
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity. 2008 Sep 19;29(3):423-37. doi: 10.1016/j.immuni.2008.06.015.
8
Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.
J Immunol. 2008 Sep 15;181(6):4072-9. doi: 10.4049/jimmunol.181.6.4072.
9
B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.
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10
Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes.
Clin Exp Immunol. 2008 Oct;154(1):141-51. doi: 10.1111/j.1365-2249.2008.03739.x. Epub 2008 Aug 22.
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